ORC1

Across TCGA patient cohorts, ORC1 mutation is significantly associated with the RNA expression of many other genes, with 3,245 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORC1-associated genes across cancer lineages are RNA5SP198, LINC01533, and TRBV7-9. Each is linked with ORC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC1-to-partner and partner-to-ORC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP198 grouped by ORC1-low versus ORC1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC1→partner) and Y-score (partner→ORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP198 →	+0.411	+6.144	<.001	.001	3	2
LUAD	LINC01533 →	+0.020	+4.612	<.001	.006	3	2
UCEC	TRBV7-9 →	+0.746	+2.595	<.001	<.001	3	2
UCEC	DHRS11 →	+0.685	+2.711	<.001	<.001	3	2
CESC	ELAVL4-AS1 →	+0.051	+5.103	.006	.008	3	2
COAD	IL21 →	+0.559	+3.082	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,245 associations by consensus.

RNA5SP198 by ORC1 expression — CESC

Explore this box plot interactively →