ORC1

Across TCGA patient cohorts, ORC1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORC1-associated genes across cancer lineages are Annexin-1, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with ORC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC1-to-partner and partner-to-ORC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by ORC1-low versus ORC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC1→partner) and Y-score (partner→ORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.457	+2.019	.012	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.614	+1.505	.002	.034	3	2
UCEC	14-3-3_beta →	-0.093	-1.780	.007	.024	3	1
UCEC	EGFR →	-0.138	-1.440	.013	.024	3	1
UCEC	eIF4E →	+0.262	+3.584	<.001	<.001	3	1
UCEC	GAPDH →	+0.487	+3.584	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Annexin-1 by ORC1 expression — UCEC

Explore this box plot interactively →