ORC1

Across TCGA cell cohorts, ORC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,007 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ORC1-associated GO terms across cancer lineages are DNA replication initiation, Regulation of G2/M transition of mitotic cell cycle, and Regulation of cell cycle checkpoint. Each is linked with ORC1 in more than 19 cancer types. Because this analysis shows association rather than direction, both ORC1-to-partner and partner-to-ORC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by ORC1-low versus ORC1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC1→partner) and Y-score (partner→ORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNA replication initiation →	+0.223	+2.013	<.001	<.001	3	20
BONE	Regulation of G2/M transition of mitotic cell cycle →	+0.091	+1.644	.004	.005	3	19
OESOPHAGUS	Regulation of cell cycle checkpoint →	+0.166	+1.772	<.001	<.001	3	19
OESOPHAGUS	Positive regulation of cell cycle phase transition →	+0.141	+1.612	<.001	<.001	3	19
PANCREAS	Regulation of cell cycle G2/M phase transition →	+0.080	+1.531	<.001	<.001	3	19
OVARY	Negative regulation of DNA-templated DNA replication →	+0.139	+1.136	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,007 associations by consensus.

DNA replication initiation by ORC1 expression — OESOPHAGUS

Explore this box plot interactively →