ORAI2

Across TCGA pan-cancer cohorts, ORAI2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ORAI2 data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ORAI2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ORAI2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC and LUAD are the cancer types where ORAI2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	1.000	0.880	.013	13	view →
LUAD	OS	Tertile	II,III,IV	0.794	0.329	.035	5	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ORAI2–LSCC (DFS)

Open the LSCC breakdown →