ORAI2

Across TCGA patient cohorts, ORAI2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORAI2-associated genes across cancer lineages are ASNS, ERK2, and GSK-3a-b_pS21_S9. Each is linked with ORAI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORAI2-to-partner and partner-to-ORAI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ORAI2-low versus ORAI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORAI2→partner) and Y-score (partner→ORAI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.503	+2.321	.002	.034	3	2
UCEC	ERK2 →	+0.194	+2.584	.030	.011	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.422	+2.179	.034	.034	3	1
UCEC	Ku80 →	+0.343	+2.598	.001	.006	3	1
UCEC	p27_pT198 →	+0.099	+2.584	.046	.011	3	1
UCEC	p62 Lck ligand →	+0.325	+2.331	.032	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ASNS by ORAI2 expression — UCEC

Explore this box plot interactively →