ORAI2

Across TCGA cell cohorts, ORAI2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ORAI2-associated genes across cancer lineages are SLC32A1, MYL7, and CSH1. Each is linked with ORAI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORAI2-to-partner and partner-to-ORAI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by ORAI2-low versus ORAI2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORAI2→partner) and Y-score (partner→ORAI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+1.070	+3.901	<.001	.006	3	1
BLOOD_Leukemia	MYL7 →	+0.063	+4.339	<.001	.002	3	1
BLOOD_Leukemia	CSH1 →	+0.044	+4.339	<.001	.002	3	1
BLOOD_Leukemia	CLDN8 →	+0.012	+4.234	<.001	.003	3	1
BLOOD_Leukemia	C16orf92 →	+0.118	+4.037	.007	.004	3	1
BLOOD_Leukemia	INSM2 →	+0.195	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SLC32A1 by ORAI2 expression — BLOOD_Leukemia

Explore this box plot interactively →