ORAI1

Across TCGA pan-cancer cohorts, ORAI1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ORAI1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ORAI1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ORAI1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC and LUAD are the cancer types where ORAI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.853	1.000	.027	14	view →
LUAD	OS	Median	II,III,IV	0.807	0.534	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ORAI1–CCRCC (OS)

Open the CCRCC breakdown →