ORAI1

Across TCGA patient cohorts, ORAI1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,900 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ORAI1-associated proteins across cancer lineages are TMPO, SRSF9, and PGAM5. Each is linked with ORAI1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ORAI1-to-partner and partner-to-ORAI1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ORAI1 versus TMPO in OV, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ORAI1→partner) and Y-score (partner→ORAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TMPO →	+0.299	+0.343	.001	.005	3	6
OV	SRSF9 →	+0.409	+0.583	<.001	.003	3	5
LSCC	PGAM5 →	+0.358	+0.378	<.001	<.001	3	4
LSCC	AQR →	+0.262	+0.421	<.001	<.001	3	4
LSCC	ZWILCH →	+0.500	+0.516	<.001	<.001	3	4
COAD	RACGAP1 →	+0.532	+0.374	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,900 associations by consensus.

ORAI1 vs TMPO — OV

Explore this scatter interactively →