ORAI1

Across TCGA cell cohorts, ORAI1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,773 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ORAI1-associated GO terms across cancer lineages are Positive regulation of cyclase activity, Protein depolymerization, and Regulation of hippo signaling. Each is linked with ORAI1 in more than 11 cancer types. Because this analysis shows association rather than direction, both ORAI1-to-partner and partner-to-ORAI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cyclase activity grouped by ORAI1-low versus ORAI1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ORAI1→partner) and Y-score (partner→ORAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of cyclase activity →	+0.158	+1.052	<.001	<.001	3	12
URINARY_TRACT	Protein depolymerization →	+0.134	+0.827	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of hippo signaling →	+0.065	+0.703	.004	.001	2	11
SKIN	Regulation of protein localization to endoplasmic reticulum →	+0.112	+1.007	<.001	<.001	3	10
BLOOD_Lymphoma	Transcription pausing by RNA polymerase II →	+0.108	+0.669	<.001	<.001	3	10
BREAST	Positive regulation of mitotic cytokinesis →	+0.137	+0.763	.002	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,773 associations by consensus.

Positive regulation of cyclase activity by ORAI1 expression — LUNG_SCLC

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