ORAI1

Across TCGA cell cohorts, ORAI1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ORAI1-associated genes across cancer lineages are C20orf85, IL22, and OR10K1. Each is linked with ORAI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORAI1-to-partner and partner-to-ORAI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by ORAI1-low versus ORAI1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORAI1→partner) and Y-score (partner→ORAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	1
BLOOD_Leukemia	IL22 →	+0.030	+4.984	<.001	.002	3	1
BLOOD_Leukemia	OR10K1 →	+0.525	+4.234	<.001	.003	3	1
BLOOD_Leukemia	OR10T2 →	+0.866	+4.691	<.001	<.001	3	1
BLOOD_Leukemia	INSYN2A →	+0.559	+4.129	<.001	.009	3	1
BLOOD_Leukemia	OR10R2 →	+2.627	+4.966	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

C20orf85 by ORAI1 expression — BLOOD_Leukemia

Explore this box plot interactively →