OR9K2

Across TCGA patient cohorts, OR9K2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR9K2-associated genes across cancer lineages are EGFR, EGFR_pY1068, and eIF4E. Each is linked with OR9K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR9K2-to-partner and partner-to-OR9K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by OR9K2-low versus OR9K2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR9K2→partner) and Y-score (partner→OR9K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EGFR →	-0.146	-3.000	.034	.034	3	2
UCEC	EGFR_pY1068 →	-0.256	-2.321	.016	.034	3	1
UCEC	eIF4E →	+0.190	+2.906	.033	.001	3	1
UCEC	eIF4G →	+0.358	+3.169	.006	.018	3	1
UCEC	FoxM1 →	+0.239	+1.700	.029	.044	3	1
UCEC	FOXO3a_pS318_S321 →	-0.145	-3.690	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

EGFR by OR9K2 expression — SKCM

Explore this box plot interactively →