OR9I1

Across TCGA patient cohorts, OR9I1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR9I1-associated genes across cancer lineages are eIF4E, Notch1, and FOXO3a_pS318_S321. Each is linked with OR9I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR9I1-to-partner and partner-to-OR9I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by OR9I1-low versus OR9I1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR9I1→partner) and Y-score (partner→OR9I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.179	+3.013	.039	.018	3	2
UCEC	Notch1 →	+0.243	+2.321	<.001	.006	3	2
UCEC	FOXO3a_pS318_S321 →	-0.127	-2.690	.013	.006	3	1
UCEC	MEK1 →	+0.423	+2.459	.005	.019	3	1
UCEC	MSH2 →	-0.229	-2.973	.016	.035	3	1
UCEC	mTOR_pS2448 →	-0.159	-1.980	.009	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eIF4E by OR9I1 expression — UCEC

Explore this box plot interactively →