OR9G4

Across TCGA patient cohorts, OR9G4 mutation is significantly associated with the RNA expression of many other genes, with 3,248 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR9G4-associated genes across cancer lineages are VPS29, KANSL2, and ENOPH1. Each is linked with OR9G4 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR9G4-to-partner and partner-to-OR9G4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VPS29 grouped by OR9G4-low versus OR9G4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR9G4→partner) and Y-score (partner→OR9G4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VPS29 →	+0.400	+2.186	.001	.001	3	3
UCEC	KANSL2 →	+0.403	+2.558	.001	<.001	3	3
UCEC	ENOPH1 →	+0.608	+2.747	<.001	<.001	3	3
SKCM	VRK1 →	+0.542	+3.350	.003	.005	3	3
LUAD	COA8 →	+0.562	+3.217	<.001	.009	3	3
UCEC	LRR1 →	+0.709	+3.828	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,248 associations by consensus.

VPS29 by OR9G4 expression — UCEC

Explore this box plot interactively →