OR9A4

Across TCGA patient cohorts, OR9A4 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR9A4-associated genes across cancer lineages are TSC1, Bak, and PAI-1. Each is linked with OR9A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR9A4-to-partner and partner-to-OR9A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSC1 grouped by OR9A4-low versus OR9A4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR9A4→partner) and Y-score (partner→OR9A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TSC1 →	-0.453	-3.000	<.001	.034	3	3
UCEC	Bak →	+0.329	+3.321	.012	.010	3	2
SKCM	PAI-1 →	+0.941	+2.601	<.001	.005	3	2
SKCM	Smad4 →	+0.161	+2.502	<.001	.001	3	2
UCEC	eEF2 →	+0.440	+3.321	.018	.010	3	1
UCEC	EGFR_pY1068 →	-0.338	-3.000	.010	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

TSC1 by OR9A4 expression — COAD

Explore this box plot interactively →