OR8K5

Across TCGA patient cohorts, OR8K5 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR8K5-associated genes across cancer lineages are PCNA, PDCD4, and mTOR_pS2448. Each is linked with OR8K5 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR8K5-to-partner and partner-to-OR8K5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by OR8K5-low versus OR8K5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8K5→partner) and Y-score (partner→OR8K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.321	+2.321	.003	.035	3	3
SKCM	PDCD4 →	-0.435	-3.000	.010	.034	3	3
LUAD	mTOR_pS2448 →	-0.315	-3.000	.002	.036	3	2
LUAD	TFRC →	+1.107	+3.000	<.001	.036	2	3
UCEC	4E-BP1 →	+0.525	+2.837	<.001	.035	2	3
SKCM	PKC-b-II_pS660 →	-0.263	-1.700	.033	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PCNA by OR8K5 expression — UCEC

Explore this box plot interactively →