OR8K1

Across TCGA pan-cancer cohorts, OR8K1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OR8K1 data layer compared with 8 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher OR8K1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OR8K1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, READ, and CESC are the cancer types where OR8K1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.108	0.703	<.001	36	view →
READ	OS	Median	II,III,IV	0.054	0.934	<.001	18	view →
CESC	DFS	Median	All	0.146	0.740	<.001	12	view →
BRCA	DFS	Median	All	0.709	0.902	.047	4	view →
UCEC	DFS	Median	II,III,IV	1.000	0.487	.038	4	view →
LUSC	DFS	Median	All	0.064	0.791	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OR8K1–ESCA (OS)

Open the ESCA breakdown →