OR8J3

Across TCGA patient cohorts, OR8J3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR8J3-associated genes across cancer lineages are JNK_pT183_Y185, FoxM1, and Ku80. Each is linked with OR8J3 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR8J3-to-partner and partner-to-OR8J3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by OR8J3-low versus OR8J3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8J3→partner) and Y-score (partner→OR8J3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.161	-2.115	.012	.017	3	4
LUAD	FoxM1 →	+0.434	+3.182	<.001	.009	3	3
LUSC	Ku80 →	+0.321	+1.901	.025	.030	3	3
UCEC	TFRC →	+0.472	+2.087	.020	.005	3	3
LUAD	GSK3-a-b →	+0.163	+3.000	.023	.035	3	2
LUAD	MSH2 →	+0.440	+3.000	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

JNK_pT183_Y185 by OR8J3 expression — UCEC

Explore this box plot interactively →