OR8H3

Across TCGA patient cohorts, OR8H3 mutation is significantly associated with the RNA expression of many other genes, with 2,072 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR8H3-associated genes across cancer lineages are RAD51, CDC6, and PGK1. Each is linked with OR8H3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR8H3-to-partner and partner-to-OR8H3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by OR8H3-low versus OR8H3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8H3→partner) and Y-score (partner→OR8H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.717	+2.098	<.001	.003	3	3
UCEC	CDC6 →	+0.661	+3.269	.002	<.001	3	3
UCEC	PGK1 →	+0.758	+2.584	.002	.001	3	3
UCEC	MLX →	+0.504	+2.955	<.001	<.001	3	3
UCEC	NDUFB3 →	+0.405	+2.151	.006	.003	3	3
UCEC	SPRYD7 →	+0.379	+3.332	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,072 associations by consensus.

RAD51 by OR8H3 expression — UCEC

Explore this box plot interactively →