OR8H3

Across TCGA cell cohorts, OR8H3 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible OR8H3-associated genes across cancer lineages are C5orf52, C9orf57, and WNT2. Each is linked with OR8H3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR8H3-to-partner and partner-to-OR8H3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf52 grouped by OR8H3-low versus OR8H3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8H3→partner) and Y-score (partner→OR8H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C5orf52 →	+0.072	+4.584	<.001	.001	3	1
LUNG_NSCLC_LUSC	C9orf57 →	+0.045	+4.584	<.001	.001	3	1
SKIN	WNT2 →	+0.643	+3.426	.002	.007	3	1
SKIN	SYT10 →	+0.283	+3.217	<.001	.006	3	1
SKIN	C4BPA →	+0.024	+3.376	<.001	.002	3	1
SKIN	NPY5R →	+0.138	+2.994	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

C5orf52 by OR8H3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →