OR8H3

Across TCGA cell cohorts, OR8H3 mutation is significantly associated with the mutation status of many other genes, with 967 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OR8H3-associated genes across cancer lineages are ZNF568, TNXB, and KCNT2. Each is linked with OR8H3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR8H3-to-partner and partner-to-OR8H3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF568 grouped by OR8H3-low versus OR8H3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8H3→partner) and Y-score (partner→OR8H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF568 →	+4.415	+4.977	.007	.007	1	3
LUNG_NSCLC_LUAD	TNXB →	+1.992	+3.118	.005	.005	1	3
BLOOD_Leukemia	KCNT2 →	+4.894	+4.894	.004	.004	1	3
BLOOD_Leukemia	TSC2 →	+2.572	+4.129	.009	.009	1	3
BLOOD_Leukemia	HDAC9 →	+5.479	+6.145	<.001	<.001	1	3
BLOOD_Leukemia	WNK1 →	+2.779	+4.326	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 967 associations by consensus.

ZNF568 by OR8H3 expression — OVARY

Explore this box plot interactively →