OR8H2

Across TCGA patient cohorts, OR8H2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR8H2-associated genes across cancer lineages are Caspase-7-cleavedD198, MIG-6, and PAI-1. Each is linked with OR8H2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR8H2-to-partner and partner-to-OR8H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by OR8H2-low versus OR8H2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8H2→partner) and Y-score (partner→OR8H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.709	+1.894	.003	.030	3	3
SKCM	MIG-6 →	+0.129	+1.502	.043	.035	3	3
SKCM	PAI-1 →	+0.845	+1.874	.001	.049	3	2
SKCM	Smad4 →	+0.121	+1.906	.007	.016	3	2
UCEC	ERK2 →	+0.222	+2.321	.005	.006	3	2
UCEC	PDCD4 →	-0.510	-1.807	.008	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Caspase-7-cleavedD198 by OR8H2 expression — UCEC

Explore this box plot interactively →