OR8H1

Across TCGA patient cohorts, OR8H1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR8H1-associated genes across cancer lineages are Chk1, c-Jun_pS73, and PCNA. Each is linked with OR8H1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR8H1-to-partner and partner-to-OR8H1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by OR8H1-low versus OR8H1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8H1→partner) and Y-score (partner→OR8H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk1 →	+0.202	+1.908	.022	.029	3	3
LUSC	c-Jun_pS73 →	-0.207	-3.000	.015	.035	3	2
UCEC	PCNA →	+0.183	+2.999	.035	.035	3	2
UCEC	PDCD4 →	-0.579	-3.321	.002	.009	3	2
UCEC	ASNS →	+0.478	+2.000	<.001	.030	3	2
UCEC	4E-BP1 →	+0.337	+3.321	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Chk1 by OR8H1 expression — SKCM

Explore this box plot interactively →