Across TCGA pan-cancer cohorts, OR8D1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of OR8D1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where OR8D1 RNA is repressed in tumor relative to normal tissue. In most cancer types OR8D1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, HNSC, and BRCA are the cancer types where OR8D1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR8D1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.202	<.001	7	view →
HNSC	Male	All	+0.031	.041	2	view →
BRCA	All	All	+0.016	.032	2	view →
LUSC	Male	All	+0.032	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: OR8D1 RNA expression & survival · all OR8D1 data types