OR8B4

Across TCGA patient cohorts, OR8B4 mutation is significantly associated with the RNA expression of many other genes, with 523 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR8B4-associated genes across cancer lineages are SPTLC1P2, OR4A42P, and HNRNPRP2. Each is linked with OR8B4 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR8B4-to-partner and partner-to-OR8B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPTLC1P2 grouped by OR8B4-low versus OR8B4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8B4→partner) and Y-score (partner→OR8B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SPTLC1P2 →	+0.173	+2.385	.003	.002	3	3
SKCM	OR4A42P →	+0.014	+4.321	<.001	.003	3	3
SKCM	HNRNPRP2 →	+0.033	+2.894	<.001	.003	3	3
LIHC	MARK3P1 →	+0.255	+5.066	<.001	.001	3	2
HNSC	MRPS21P7 →	+0.187	+5.339	<.001	.003	3	2
HNSC	MIR4672 →	+0.499	+4.536	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 523 associations by consensus.

SPTLC1P2 by OR8B4 expression — LUSC

Explore this box plot interactively →