OR8B4

Across TCGA patient cohorts, OR8B4 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR8B4-associated genes across cancer lineages are Caspase-7-cleavedD198, p90 RSK, and Bim. Each is linked with OR8B4 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR8B4-to-partner and partner-to-OR8B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by OR8B4-low versus OR8B4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8B4→partner) and Y-score (partner→OR8B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Caspase-7-cleavedD198 →	+0.550	+2.825	.019	.033	3	4
LUSC	p90 RSK →	-0.221	-2.981	.008	.033	3	2
LUSC	Bim →	+0.353	+2.179	.008	.035	3	1
SKCM	PREX1 →	-0.507	-2.567	<.001	.011	3	1
UCEC	GSK-3_pS9 →	-0.619	-3.169	.005	.020	3	1
UCEC	PDCD4 →	-0.677	-2.990	.008	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Caspase-7-cleavedD198 by OR8B4 expression — LUSC

Explore this box plot interactively →