OR8B4

Across TCGA cell cohorts, OR8B4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OR8B4-associated genes across cancer lineages are LRRC53, OR6B2, and GLT6D1. Each is linked with OR8B4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR8B4-to-partner and partner-to-OR8B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC53 grouped by OR8B4-low versus OR8B4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8B4→partner) and Y-score (partner→OR8B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LRRC53 →	+0.013	+4.813	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR6B2 →	+0.029	+4.442	<.001	.004	3	1
LUNG_NSCLC_LUAD	GLT6D1 →	+0.003	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	BTNL2 →	+0.058	+3.760	.009	.008	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

LRRC53 by OR8B4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →