OR7G2

Across TCGA patient cohorts, OR7G2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR7G2-associated genes across cancer lineages are PKC-b-II_pS660, CDK1, and FOXO3a_pS318_S321. Each is linked with OR7G2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR7G2-to-partner and partner-to-OR7G2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by OR7G2-low versus OR7G2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR7G2→partner) and Y-score (partner→OR7G2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.451	-3.169	.002	.020	3	2
SKCM	CDK1 →	+0.155	+3.321	.040	.009	3	2
UCEC	FOXO3a_pS318_S321 →	-0.203	-2.999	.003	.035	3	1
UCEC	JNK2 →	+0.238	+3.169	.029	.020	3	1
UCEC	STAT3_pY705 →	-0.519	-3.169	<.001	.020	3	1
UCEC	BRD4 →	+0.303	+2.818	.039	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

PKC-b-II_pS660 by OR7G2 expression — UCEC

Explore this box plot interactively →