OR6T1

Across TCGA patient cohorts, OR6T1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR6T1-associated genes across cancer lineages are Cyclin-B1, Beclin, and ACC_pS79. Each is linked with OR6T1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR6T1-to-partner and partner-to-OR6T1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by OR6T1-low versus OR6T1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR6T1→partner) and Y-score (partner→OR6T1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.758	+2.906	.001	.001	3	3
LUSC	Beclin →	-0.133	-3.294	.042	.010	3	2
SKCM	ACC_pS79 →	+0.266	+1.584	.019	.035	3	2
SKCM	MIG-6 →	+0.135	+2.484	.029	.010	3	2
UCEC	VHL →	-1.322	-3.700	<.001	.001	3	2
SKCM	YAP_pS127 →	-0.306	-2.000	.028	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Cyclin-B1 by OR6T1 expression — UCEC

Explore this box plot interactively →