OR6S1

Across TCGA pan-cancer cohorts, OR6S1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated OR6S1 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher OR6S1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OR6S1 expression acts as an unfavorable survival marker, although some lineages such as OV and HNSC show a favorable association.

KIRC, ACC, and OV are the cancer types where OR6S1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.513	0.664	<.001	98	view →
ACC	DFS	Tertile	All	0.108	0.673	.001	72	view →
OV	DFS	Tertile	III,IV	0.389	0.145	.004	66	view →
MESO	OS	Tertile	IV	0.115	0.671	<.001	63	view →
CESC	DFS	Tertile	IV	0.236	0.554	.032	42	view →
HNSC	OS	Tertile	III,IV	0.437	0.294	.017	42	view →
ESCA	OS	Median	IV	0.698	0.222	.006	42	view →
COAD	OS	Tertile	IV	0.172	0.671	.001	27	view →
UCS	DFS	Tertile	II,III,IV	0.177	0.471	.028	18	view →
SKCM	DFS	Tertile	III,IV	0.388	0.229	.035	15	view →
LUAD	DFS	Tertile	IV	0.671	0.893	.019	12	view →
LIHC	DFS	Tertile	III,IV	0.129	0.433	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

OR6S1–KIRC (OS)

Open the KIRC breakdown →