OR6K6

Across TCGA patient cohorts, OR6K6 mutation is significantly associated with the RNA expression of many other genes, with 1,060 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR6K6-associated genes across cancer lineages are TRAJ13, DHRS11, and AUNIP. Each is linked with OR6K6 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR6K6-to-partner and partner-to-OR6K6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ13 grouped by OR6K6-low versus OR6K6-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR6K6→partner) and Y-score (partner→OR6K6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAJ13 →	+0.513	+4.518	.005	.002	3	2
SKCM	DHRS11 →	+0.469	+1.826	.002	.002	3	2
LUSC	AUNIP →	+0.642	+2.724	.001	.003	3	2
LUSC	LAS1L →	+0.409	+2.735	.003	.003	3	2
LUSC	COPG2 →	+0.517	+3.878	.003	<.001	3	2
LUSC	EXOSC10 →	+0.389	+2.700	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,060 associations by consensus.

TRAJ13 by OR6K6 expression — HNSC

Explore this box plot interactively →