OR6K6

Across TCGA patient cohorts, OR6K6 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible OR6K6-associated genes across cancer lineages are CD49b, Ku80, and MYH11. Each is linked with OR6K6 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR6K6-to-partner and partner-to-OR6K6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by OR6K6-low versus OR6K6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR6K6→partner) and Y-score (partner→OR6K6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CD49b →	+0.309	+2.331	.039	.019	3	3
LUSC	Ku80 →	+0.458	+3.000	.002	.035	3	2
SKCM	MYH11 →	-0.731	-3.169	.044	.017	3	2
UCEC	PCNA →	+0.207	+2.459	.047	.020	3	2
LUSC	MAPK_pT202_Y204 →	-0.399	-3.000	.014	.033	3	1
LUSC	MSH6 →	+0.432	+3.468	.019	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

CD49b by OR6K6 expression — LUSC

Explore this box plot interactively →