OR6K6

Across TCGA cell cohorts, OR6K6 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR6K6-associated genes across cancer lineages are NLRP8, KRTAP17-1, and PAK5. Each is linked with OR6K6 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR6K6-to-partner and partner-to-OR6K6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP8 grouped by OR6K6-low versus OR6K6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR6K6→partner) and Y-score (partner→OR6K6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NLRP8 →	+0.054	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP17-1 →	+0.032	+5.228	<.001	.005	3	1
SKIN	PAK5 →	+0.048	+3.658	.008	.005	3	1
SKIN	AQP8 →	+0.025	+4.029	.007	.002	3	1
SKIN	MYL7 →	+0.274	+3.345	.006	.007	3	1
SKIN	ODF1 →	+0.013	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

NLRP8 by OR6K6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →