OR6C2

Across TCGA patient cohorts, OR6C2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR6C2-associated genes across cancer lineages are p38-MAPK_pT180_Y182, ACC_pS79, and MYH11. Each is linked with OR6C2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR6C2-to-partner and partner-to-OR6C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by OR6C2-low versus OR6C2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR6C2→partner) and Y-score (partner→OR6C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p38-MAPK_pT180_Y182 →	-0.294	-2.442	.014	.017	3	2
SKCM	ACC_pS79 →	+0.254	+2.000	.011	.027	3	1
SKCM	MYH11 →	-0.816	-3.807	.006	<.001	3	1
SKCM	p53 →	+0.190	+1.713	.003	.024	3	1
SKCM	PCNA →	+0.182	+2.584	.006	.009	3	1
SKCM	AMPK_alpha →	+0.097	+1.440	.045	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

p38-MAPK_pT180_Y182 by OR6C2 expression — SKCM

Explore this box plot interactively →