OR5T3

Across TCGA patient cohorts, OR5T3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5T3-associated genes across cancer lineages are Rb_pS807_S811, Di-Ras3, and Rab11. Each is linked with OR5T3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5T3-to-partner and partner-to-OR5T3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rb_pS807_S811 grouped by OR5T3-low versus OR5T3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5T3→partner) and Y-score (partner→OR5T3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Rb_pS807_S811 →	+0.392	+3.000	.027	.035	3	2
UCEC	Di-Ras3 →	-0.125	-2.986	.031	.035	3	2
LUAD	Rab11 →	-0.129	-2.000	.031	.031	3	1
LUAD	4E-BP1_pS65 →	+0.174	+3.182	.003	.009	3	1
LUSC	HER2 →	+0.471	+2.709	.001	.003	3	1
LUSC	PDCD4 →	+0.452	+3.584	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Rb_pS807_S811 by OR5T3 expression — LUSC

Explore this box plot interactively →