OR5R1

mutation — cross-omics
Cross-omicsMUTATION → DRUGCell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, OR5R1 mutation is significantly associated with the drug of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR5R1-associated genes across cancer lineages are Niraparib, 50869, and 776928. Each is linked with OR5R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5R1-to-partner and partner-to-OR5R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by OR5R1-low versus OR5R1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5R1→partner) and Y-score (partner→OR5R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LARGE_INTESTINENiraparib →+0.361+2.868.032.02231
LARGE_INTESTINE50869 →+0.450+2.678.033.03731
LARGE_INTESTINE776928 →+0.668+2.710.035.02731
LARGE_INTESTINEKRAS (G12C) Inhibitor-12 →+0.478+2.868.044.02231
LARGE_INTESTINEAra-G →+0.175+2.722.037.04031
LARGE_INTESTINEBEN →+0.780+2.649.032.04621
Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Niraparib by OR5R1 expression — LARGE_INTESTINE

Box plot of Niraparib in OR5R1-low vs OR5R1-high samples in LARGE_INTESTINE.

Explore this box plot interactively →

Exploration