OR5P3

Across TCGA patient cohorts, OR5P3 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5P3-associated genes across cancer lineages are eIF4E, p53, and PDCD4. Each is linked with OR5P3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5P3-to-partner and partner-to-OR5P3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by OR5P3-low versus OR5P3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5P3→partner) and Y-score (partner→OR5P3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.226	+2.820	.033	.035	3	2
SKCM	p53 →	+0.177	+2.128	.015	.009	3	1
SKCM	PDCD4 →	-0.392	-1.584	.012	.035	3	1
SKCM	ARID1A →	-0.151	-3.430	.008	.004	3	1
UCEC	PCNA →	+0.301	+2.321	.005	.035	3	1
UCEC	Caspase-8 →	-0.289	-2.973	.022	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

eIF4E by OR5P3 expression — UCEC

Explore this box plot interactively →