OR5M8

Across TCGA patient cohorts, OR5M8 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5M8-associated genes across cancer lineages are 4E-BP1, p70-S6K_pT389, and TFRC. Each is linked with OR5M8 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR5M8-to-partner and partner-to-OR5M8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by OR5M8-low versus OR5M8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5M8→partner) and Y-score (partner→OR5M8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.338	+3.351	.003	.005	3	3
UCEC	p70-S6K_pT389 →	-0.210	-3.321	.009	.009	3	2
UCEC	TFRC →	+0.523	+2.906	.020	.001	3	2
UCEC	4E-BP1_pT70 →	+0.098	+1.700	.044	.044	3	2
UCEC	Cyclin-B1 →	+0.539	+1.700	.023	.044	3	2
LUAD	RBM15 →	+0.564	+2.824	.003	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

4E-BP1 by OR5M8 expression — UCEC

Explore this box plot interactively →