OR5M3

Across TCGA patient cohorts, OR5M3 mutation is significantly associated with the RNA expression of many other genes, with 1,905 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5M3-associated genes across cancer lineages are NDUFAF5, LRRC59, and TMPO. Each is linked with OR5M3 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR5M3-to-partner and partner-to-OR5M3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF5 grouped by OR5M3-low versus OR5M3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5M3→partner) and Y-score (partner→OR5M3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFAF5 →	+0.416	+3.959	<.001	<.001	3	3
UCEC	LRRC59 →	+0.584	+2.673	<.001	<.001	3	3
UCEC	TMPO →	+0.651	+2.695	.003	<.001	3	3
UCEC	KIF18A →	+0.712	+2.180	<.001	.002	3	3
UCEC	ZWINT →	+0.835	+2.906	<.001	.001	3	3
UCEC	SLF1 →	+0.456	+2.662	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,905 associations by consensus.

NDUFAF5 by OR5M3 expression — UCEC

Explore this box plot interactively →