OR5M1

Across TCGA patient cohorts, OR5M1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5M1-associated genes across cancer lineages are 4E-BP1_pT37_T46, JNK_pT183_Y185, and TFRC. Each is linked with OR5M1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR5M1-to-partner and partner-to-OR5M1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by OR5M1-low versus OR5M1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5M1→partner) and Y-score (partner→OR5M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	4E-BP1_pT37_T46 →	-0.483	-2.691	.027	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.156	-3.321	.018	.009	3	2
SKCM	TFRC →	+0.688	+3.169	.005	.017	3	2
UCEC	4E-BP1 →	+0.266	+3.489	.012	.002	3	2
LUSC	MAPK_pT202_Y204 →	-0.316	-1.990	.030	.031	3	1
LUSC	Akt_pT308 →	-0.451	-3.000	.011	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

4E-BP1_pT37_T46 by OR5M1 expression — LUSC

Explore this box plot interactively →