OR5L1

Across TCGA patient cohorts, OR5L1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible OR5L1-associated genes across cancer lineages are MMP20, AKR1C2, and COX7B2. Each is linked with OR5L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5L1-to-partner and partner-to-OR5L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP20 grouped by OR5L1-low versus OR5L1-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5L1→partner) and Y-score (partner→OR5L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	MMP20 →	+0.048	+2.744	.003	.008	3	1
SCLC	AKR1C2 →	+1.071	+3.108	<.001	.003	3	1
SCLC	COX7B2 →	+0.488	+3.174	.004	.001	3	1
SCLC	OR7A17 →	+0.033	+3.643	<.001	.009	3	1
SCLC	OR52B4 →	+0.041	+3.321	<.001	.001	3	1
SCLC	ARTN →	+1.754	+3.424	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MMP20 by OR5L1 expression — SCLC

Explore this box plot interactively →