Across TCGA pan-cancer cohorts, OR5K3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated OR5K3 data layer compared with 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher OR5K3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated OR5K3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, ESCA, and UCEC are the cancer types where OR5K3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.066	0.667	.002	12	view →
ESCA	OS	Median	All	0.198	0.872	.003	12	view →
UCEC	DFS	Median	All	0.951	0.623	.041	4	view →
BRCA	DFS	Median	All	0.238	0.528	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: OR5K3 tumor-vs-normal RNA expression · all OR5K3 data types