OR5K2

Across TCGA patient cohorts, OR5K2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5K2-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with OR5K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5K2-to-partner and partner-to-OR5K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by OR5K2-low versus OR5K2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5K2→partner) and Y-score (partner→OR5K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.604	+3.479	.019	.002	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.115	.018	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.148	-3.000	.044	.036	3	1
UCEC	JNK2 →	+0.215	+2.115	.013	.019	3	1
UCEC	PCNA →	+0.238	+2.459	.011	.019	3	1
UCEC	Rad50 →	-0.266	-2.115	.012	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-7-cleavedD198 by OR5K2 expression — UCEC

Explore this box plot interactively →