OR5K2

Across TCGA cell cohorts, OR5K2 mutation is significantly associated with the drug of many other genes, with 49 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR5K2-associated genes across cancer lineages are Gemcitabine, Epirubicin, and Luminespib. Each is linked with OR5K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5K2-to-partner and partner-to-OR5K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gemcitabine grouped by OR5K2-low versus OR5K2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5K2→partner) and Y-score (partner→OR5K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Gemcitabine →	+0.798	+2.807	.038	.046	3	1
LARGE_INTESTINE	Epirubicin →	+0.583	+2.871	.027	.021	3	1
LARGE_INTESTINE	Luminespib →	+0.578	+2.868	.046	.022	3	1
LARGE_INTESTINE	Entospletinib →	+0.423	+2.868	.019	.022	3	1
LARGE_INTESTINE	PRT062607 →	+0.537	+2.777	.024	.030	3	1
LARGE_INTESTINE	Topotecan →	+0.509	+2.871	.035	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Gemcitabine by OR5K2 expression — LARGE_INTESTINE

Explore this box plot interactively →