OR5I1

Across TCGA patient cohorts, OR5I1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5I1-associated genes across cancer lineages are p27_pT157, Cyclin-E2, and STAT3_pY705. Each is linked with OR5I1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR5I1-to-partner and partner-to-OR5I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by OR5I1-low versus OR5I1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5I1→partner) and Y-score (partner→OR5I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	p27_pT157 →	+0.090	+2.844	.032	.032	3	3
UCEC	Cyclin-E2 →	+0.157	+2.662	.013	<.001	3	3
UCEC	STAT3_pY705 →	-0.541	-4.392	<.001	<.001	3	2
SKCM	CD31 →	+0.279	+2.321	<.001	.035	3	2
UCEC	Notch1 →	+0.187	+2.169	<.001	.003	3	2
UCEC	ASNS →	+0.542	+2.584	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

p27_pT157 by OR5I1 expression — LUSC

Explore this box plot interactively →