OR5I1

Across TCGA cell cohorts, OR5I1 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OR5I1-associated genes across cancer lineages are OR4N4, DAZ4, and GZMK. Each is linked with OR5I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5I1-to-partner and partner-to-OR5I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4N4 grouped by OR5I1-low versus OR5I1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5I1→partner) and Y-score (partner→OR5I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR4N4 →	+0.120	+3.643	<.001	.007	3	2
LARGE_INTESTINE	DAZ4 →	+0.109	+2.977	.008	.006	3	2
BREAST	GZMK →	+0.056	+5.169	<.001	.005	3	2
LUNG_NSCLC_LUAD	GTSF1L →	+0.037	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	TMEM95 →	+0.015	+3.544	.004	.009	3	1
LUNG_NSCLC_LUAD	TSBP1 →	+0.088	+3.544	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

OR4N4 by OR5I1 expression — CNS

Explore this box plot interactively →