OR5H1

Across TCGA patient cohorts, OR5H1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5H1-associated genes across cancer lineages are GAPDH, Cyclin-B1, and FoxM1. Each is linked with OR5H1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR5H1-to-partner and partner-to-OR5H1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by OR5H1-low versus OR5H1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5H1→partner) and Y-score (partner→OR5H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.744	+3.459	.002	.005	3	3
UCEC	Cyclin-B1 →	+0.852	+3.459	<.001	.005	3	3
LUSC	FoxM1 →	+0.400	+2.825	.002	.033	3	2
UCEC	TFRC →	+0.743	+2.700	.001	.006	3	2
UCEC	4E-BP1 →	+0.494	+3.169	<.001	.018	3	2
SKCM	A-Raf_pS299 →	-0.144	-2.000	.025	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

GAPDH by OR5H1 expression — UCEC

Explore this box plot interactively →