OR5H1

Across TCGA cell cohorts, OR5H1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible OR5H1-associated genes across cancer lineages are SHCBP1L, C12orf40, and HBD. Each is linked with OR5H1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5H1-to-partner and partner-to-OR5H1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHCBP1L grouped by OR5H1-low versus OR5H1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5H1→partner) and Y-score (partner→OR5H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SHCBP1L →	+0.241	+3.232	.004	.008	3	1
LUNG_SCLC	C12orf40 →	+0.025	+4.058	<.001	.001	3	1
LUNG_SCLC	HBD →	+0.088	+3.765	.009	.006	3	1
LUNG_SCLC	LBHD2 →	+0.525	+3.070	<.001	.009	3	1
LARGE_INTESTINE	RASGEF1C →	+0.281	+3.626	<.001	.001	3	1
LARGE_INTESTINE	EOMES →	+0.443	+3.363	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SHCBP1L by OR5H1 expression — LUNG_SCLC

Explore this box plot interactively →