OR5F1

Across TCGA patient cohorts, OR5F1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5F1-associated genes across cancer lineages are ER-alpha_pS118, Rab25, and VHL. Each is linked with OR5F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5F1-to-partner and partner-to-OR5F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by OR5F1-low versus OR5F1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5F1→partner) and Y-score (partner→OR5F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ER-alpha_pS118 →	+0.158	+1.750	<.001	.049	3	2
UCEC	Rab25 →	-0.300	-2.321	.013	.033	3	2
UCEC	VHL →	-0.882	-1.678	<.001	.021	3	2
UCEC	STAT5a →	+0.350	+1.502	.017	.030	3	2
UCEC	Tuberin →	+0.347	+1.847	<.001	.008	3	2
LUAD	PKC-delta_pS664 →	-0.136	-2.305	.014	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ER-alpha_pS118 by OR5F1 expression — LUSC

Explore this box plot interactively →