Across TCGA pan-cancer cohorts, OR5B21 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of OR5B21’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where OR5B21 RNA is repressed in tumor relative to normal tissue. In most cancer types OR5B21 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

LUSC, STAD, and THCA are the cancer types where OR5B21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR5B21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.018	.014	3	view →
STAD	Female	All	+0.077	.030	2	view →
THCA	All	All	−0.014	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: OR5B21 RNA expression & survival · all OR5B21 data types