OR5AS1

Across TCGA pan-cancer cohorts, OR5AS1 Mutation is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated OR5AS1 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher OR5AS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OR5AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

BLCA, LIHC, and SARC are the cancer types where OR5AS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	IV	0.085	0.599	<.001	12	view →
LIHC	DFS	Median	II,III,IV	0.040	0.427	<.001	12	view →
SARC	OS	Median	All	0.224	0.839	<.001	6	view →
GBM	OS	Median	All	0.075	0.413	.003	6	view →
LUSC	DFS	Median	All	0.812	0.367	.016	5	view →
SCLC	DFS	Median	II,III,IV	0.260	0.795	.011	3	view →
PRAD	DFS	Median	All	0.391	0.812	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

OR5AS1–BLCA (OS)

Open the BLCA breakdown →